NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system
DOI
https://doi.org/10.1371/journal.pntd.0007045
Document Type
Article
Publication Date
12-1-2018
Publication Title
PLoS Neglected Tropical Diseases
Abstract
Background: Myriad infectious and noninfectious causes of encephalomyelitis (EM) have similar clinical manifestations, presenting serious challenges to diagnosis and treatment. Metabolomics of cerebrospinal fluid (CSF) was explored as a method of differentiating among neurological diseases causing EM using a single CSF sample. Methodology/Principal findings: H NMR metabolomics was applied to CSF samples from 27 patients with a laboratory-confirmed disease, including Lyme disease or West Nile Virus meningoencephalitis, multiple sclerosis, rabies, or Histoplasma meningitis, and 25 controls. Cluster analyses distinguished samples by infection status and moderately by pathogen, with shared and differentiating metabolite patterns observed among diseases. CART analysis predicted infection status with 100% sensitivity and 93% specificity. Conclusions/Significance: These preliminary results suggest the potential utility of CSF metabolomics as a rapid screening test to enhance diagnostic accuracies and improve patient outcomes. 1
Volume
12
Issue
12
ISSN
19352727
Recommended Citation
French, Caitlin D.; Willoughby, Rodney E.; Pan, Amy; Wong, Susan J.; Foley, John F.; Wheat L., Joseph; Fernandez, Josefina; Encarnacion, Rafael; Ondrush, Joanne M.; Fatteh, Naaz; Paez, Andres; David, Dan; Javaid, Waleed; Amzuta, Ioana G.; Neilan, Anne M.; Robbins, Gregory K.; Brunner, Andrew M.; Hu, William T.; Mishchuk, Darya O.; and Slupsky, Carolyn M., "NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system" (2018). Scopus Unisalle. 218.
https://ciencia.lasalle.edu.co/scopus_unisalle/218
PubMed ID
30557317
Identifier
SCOPUS_ID:85059266951