Title

Antioxidant activity of ethanolic extracts and alkaloid fractions from seeds of three species of annona

Document Type

Article

Publication Date

8-30-2018

Publication Title

Pharmacologyonline

Abstract

On Alzheimer's disease, the oxidative stress is one of the causes of neuronal death (product of the exacerbation of free radicals), for that reason the natural compounds with antioxidant properties, it is a target on the design of drugs with neuroprotective potential. In Colombia, the Annonaceae family exhibits a high economic importance, with a high variety of species with edible fruits. Some of these species have been recognized by their medicinal and insecticides properties. However, the pharmacological potential of the seeds (post-consumer residue) have not being contemplated even with a big diversity of alkaloids, which they have been attributed to important biological properties. In this sense, this study evaluated the antioxidant activity of seeds of Annona muricata, Annona cherimola and Annona squamosa. The antioxidant potential of crude extracts and alkaloid fractions was evaluated through free radical scavenging activity (DPPH) and ferric reducing potential (FRAP), these results were expressed as µmol TE / g of extract. In relation to the antioxidant potential, it has been verified that acid-base extraction of the ethanolic extracts improved the antioxidant capacity. The CHCl : EtOH fraction of A. squamosa on DPPH assay and CHCl fraction of A. muricata on FRAP assay were the alcaloidal fractions with the highest activity. This work contributes to the phytochemical knowledge of post-consumption residues, which allow evidencing its potential for obtaining natural antioxidants as an alternative in the treatment of the disease. 3 3

Volume

2

First Page

206

Last Page

218

Identifier

SCOPUS_ID:85059614694

Documento original

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