Title
Butaphosphan effects on glucose metabolism involve insulin signaling and depends on nutritional plan
DOI
https://doi.org/10.3390/nu12061856
Document Type
Article
Publication Date
6-1-2020
Publication Title
Nutrients
Abstract
Butaphosphan is an organic phosphorus compound used in several species for the prevention of rapid catabolic states, however, the mechanism of action remains unclear. This study aimed at determining the effects of butaphosphan on energy metabolism of mice receiving a normal or hypercaloric diet (HCD) and submitted or not to food restriction. Two experiments were conducted: (1) during nine weeks, animals were fed with HCD (n = 28) ad libitum, and at the 10th week, were submitted to food restriction and received butaphosphan (n = 14) or saline injections (n = 14) (twice a day, for seven days) and; (2) during nine weeks, animals were fed with a control diet (n = 14) or HCD (n = 14) ad libitum, and at the 10th week, all animals were submitted to food restriction and received butaphosphan or saline injections (twice a day, for seven days). In food restriction, butaphosphan preserved epididymal white adipose tissue (WAT) mass, increased glucose, NEFA, and the HOMA index. In mice fed HCD and submitted to food restriction, the butaphosphan preserved epididymal WAT mass. Control diet influences on PI3K, GCK, and Irs1 mRNA expression. In conclusion, butaphosphan increased blood glucose and reduced fat mobilization in overweight mice submitted to caloric restriction, and these effects are influenced by diet.
Volume
12
Issue
6
First Page
1
Last Page
13
Recommended Citation
Agnes Weiller, Maria Amélia; Alvarado-Rincón, Joao Alveiro; Bespalhok Jacometo, Carolina; Castilho Barros, Carlos; Custódio de Souza, Izabel Cristina; Hax, Lucas Teixeira; da Silva, Thaís Casarin; Mattei, Patrícia; Barbosa, Antônio Amaral; Feijó, Josiane de Oliveira; Alves Pereira, Rubens; Brauner, Cassio Cassal; Rabassa, Viviane Rohrig; Burkert del Pino, Francisco Augusto; and Nunes Corrêa, Marcio, "Butaphosphan effects on glucose metabolism involve insulin signaling and depends on nutritional plan" (2020). Scopus Unisalle. 75.
https://ciencia.lasalle.edu.co/scopus_unisalle/75
PubMed ID
32580324
Identifier
SCOPUS_ID:85087098823